In 1938, an 18-year-old Isaac Asimov penned his inaugural foray into science fiction, envisioning mans maiden voyage into space - with a twist. The short story told the tale of a technologist pushing humanity to intimidating new heights, while facing opposition from a neo-luddite movement concerned about existential doom, one that would eventually incite an employee to sabotage the company in the name of saving humanity.
Correction: Trends was one of Asimov's first short stories, not literally the first.